New insights into symptoms and neurocircuit function of anorexia nervosa pdf

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Neurobiology of Eating Disorders: Clinical Implications

New insights into neural pathways that play a role in anorexia nervosa, bulimia nervosa, and binge eating disorder. Eating disorder behaviors can range from dangerous caloric restriction to eating that feels out of control-often combined with unhealthy weight control behaviors, such as self-induced vomiting or laxative abuse.

Anorexia nervosa, bulimia nervosa, and binge eating disorder are the most prevalent eating disorders. Criteria for bulimia nervosa include recurrent binge eating eating a large amount of food in a discrete period of time accompanied by a sense of loss of control and actions meant to counteract weight gain eg, self-induced vomiting , as well as overvaluation of body weight or shape. Binge eating disorder involves recurrent binge eating without inappropriate compensatory behavior.

Individuals with eating disorders frequently report extreme body dissatisfaction, anhedonia, anxiety, and difficulty tolerating negative emotions, although these are not required for diagnosis. The cause of eating disorders remains unknown. Given that eating disorders reflect a discrepancy between the physiological need to eat and the drive to eat, it has been hypothesized that these individuals have a fundamental disturbance of appetite regulation.

In recent years, advances in brain imaging have provided new insights into neural pathways that play a role in emotions, reward, salience, and inhibition of eating. Mabel is a year-old girl who is hospitalized with unstable vital signs and a BMI of Her family describes her as an anxious, shy, and perfectionistic child who tended to ruminate about academics, social relationships and, more recently, food.

Mabel says that she has always been a picky eater. She started to lose weight after she got braces and switched to softer foods 2 years ago. She reports that her food rules became progressively more restrictive and she began exercising regularly.

She became increasingly anhedonic, cognitively rigid, and sensitive to perceived criticism. Current treatments-psychotherapy or pharmacotherapy-often have limited efficacy in ameliorating eating disorder symptoms and may not fully normalize eating behavior. Furthermore, many psychological interventions used to treat eating disorders are adaptations of treatments for other psychiatric disorders eg, depression, anxiety and were not developed for the specific, unique needs of patients with eating disorders.

The lack of a mechanistic understanding of eating disorders has thwarted efforts to develop more powerful, evidence-based interventions. Alterations in brain circuitry linked to reward and inhibition in particular appear to be involved in the maladaptive eating behavior characteristic of anorexia nervosa, bulimia nervosa, and binge eating disorder. What is it about the brains of those with eating disorders that might drive dysfunctional eating behavior?

It is well known that gut and hypothalamic mechanisms contribute to the regulation of energy metabolism and eating behaviors. However, in recent years, studies in humans have revealed that higher-order, corticolimbic systems likely play a role in the pathophysiology of eating disorders. The first of these networks codes for perceived importance of a food stimulus and comprises the insula and anterior cingulate.

The insula, along with the frontal operculum, also processes basic sensory information about food. The second pathway includes the nucleus accumbens, putamen, and caudate, as well as the orbitofrontal cortex and amygdala. These regions code for the rewarding and motivating value of eating and contribute to approach or avoidance behavior. The third network helps control consumption based on consideration of both short- and long-term outcomes eg, weight gain. It includes the dorsal caudate and dorsal anterior cingulate, lateral prefrontal cortex, and parietal cortex.

These systems interactively weigh the reward value of food and the consequences of consuming it, and they integrate this information with homeostatic and motivational drives to guide eating behavior.

Mounting evidence suggests that an altered balance of reward and inhibition may contribute to disordered eating. In contrast, dysregulation of both inhibitory and reward drives may manifest in the alternating over- and under-consumption characteristic of bulimia nervosa. Binge eating disorder may be related to altered sensitivity of ventral reward regions. Findings also suggest that these brain-based differences are linked to temperament traits, such as anxiety and harm avoidance, which persist after remission and may underlie the development of eating pathology.

The brain has different responses to the anticipation and consumption of food. People with binge eating-bulimia nervosa or binge eating disorder-demonstrate reduced response when anticipating food reward in the insula and ventral striatum, but increased response to the receipt of food in these same regions.

Alternatively, individuals with anorexia nervosa demonstrate increased and anxious sweet-taste anticipation in the insula, striatum, and prefrontal cortex and reduced responses in the insula and striatum to the tastes themselves.

Processing of other salient stimuli also seems to be altered, which suggests a generalized deficit. In healthy individuals, the ventral striatum and dorsal caudate typically show greater responses to reward than to punishment. In contrast, imaging research in eating disorders demonstrates dysfunctional neural valuation of reward and punishment. Individuals with eating disorders also have problems with inhibitory control.

Individuals with bulimia nervosa and binge eating disorder frequently demonstrate reduced inhibition that extends beyond food eg, substance use, shoplifting, self-injury. Neuroimaging studies suggest this may relate to failure to appropriately engage frontostriatal circuits that regulate behavior. Some functional MRI fMRI findings show that adults and adolescents with bulimia nervosa have reduced inhibitory activation.

Enhanced cognitive control in anorexia nervosa may contribute to an ability to restrict intake even when emaciated. Recent fMRI studies of individuals with anorexia nervosa reveal increased activity within dorsolateral cognitive circuitry associated with decision-making and inhibitory control see Figure 2.

Mabel explains that her difficulty with eating is driven by a lack of interest in food and increased anxiety about making meal choices. She reports that without a structured meal plan, she fasts to avoid the negative thoughts and mood that accompany eating. She also reports significant physical discomfort eg, bloating after eating a small amount of food.

To avoid discomfort, when unsupervised, she typically eats only yogurt and small bites of fruit and vegetables in the evening. She is also quite anhedonic. This case suggests both under- response to reward and over-control, despite extreme nutritional deprivation. It also suggests that external structure may be effective in helping Mabel restore weight. There are many similarities between substance abuse and eating disorders, particularly bulimia nervosa and binge eating disorder, including problems in the interconnected reward and inhibitory circuits.

Meta-analyses suggest increased rates of drug and alcohol abuse in persons with bulimia nervosa. Women and adolescent girls with bulimia nervosa or binge eating disorder show deficient activation in brain regions related to inhibitory control similar to patterns of activation reported in drug and alcohol users. In contrast, rates of drug and alcohol abuse are decreased in patients with anorexia nervosa. Individuals with anorexia nervosa demonstrate opposite patterns of neural activation in response to reward compared with persons with bulimia nervosa, binge eating disorder, or substance abuse.

The over-control of individuals with anorexia nervosa, particularly those with the restricting subtype, may protect them from developing dysregulated substance use disorders.

Some pharmacological treatments have shown success. Fluoxetine is currently considered the gold-standard medication for bulimia nervosa and is the only FDA-approved agent for the treatment of this disorder. Lisdexamfetamine, an appetite-suppressing amphetamine, is the only medication that is FDA-approved specifically for treating binge eating disorder.

Results of pharmacological treatment studies for anorexia nervosa have been mixed despite frequent off-label use. Viewing eating pathology from the perspective of an altered balance in self-regulatory control and reward processing provides a foundation for developing more specific, effective interventions for these debilitating disorders.

Current treatments for eating disorders, particularly for chronic anorexia nervosa in adults, are inadequate. Randomized, controlled trials of cognitive and psychodynamic treatments suggest that neither differs from treatment as usual in promoting weight restoration, and many patients drop out of treatment before full weight restoration.

Treatment of adolescent anorexia nervosa is more promising: considerable evidence supports the use of family-based treatment FBT. Parent utilization addresses the motivational deficits inherent in anorexia nervosa. Despite the effectiveness of this treatment in younger patients, to date there have been no published results of clinical trials of FBT in adults.

Adult anorexia nervosa treatment may be improved by enlisting caretakers to oversee recovery-oriented behaviors in a modified, age-appropriate manner. Treatment of anorexia nervosa in adults may also be improved by directly targeting the brain-based temperament traits characteristic of the disorder. Imaging studies in adults who have anorexia nervosa have shown that differences in reward processing are linked to elevated anxiety or harm avoidance.

If clinicians can work with these traits rather than against them, treatment effectiveness may improve. After discharge from the hospital, Mabel, her mother, and her sister begin taking part in a brief intensive family treatment program. They devise a contingency management plan eg, behavioral contract to establish a system of external rewards and consequences to reduce eating disorder behaviors.

Mabel reports decreased anxiety about meals when she knows what to expect and expresses a desire to avoid the negative consequences of reduced time with friends that is built into her contract if she engages in eating disorder behavior. Eating disorders are chronic and debilitating illnesses, and current treatments are ineffective for many patients.

Neuroimaging research suggests eating disorder symptoms may result from dysfunction in circuits underlying reward and inhibition. The brain-based temperament traits of eating disorders are stable across illness and recovery. This suggests that treatments that work with these traits and target disturbances in inhibitory control, reward sensitivity, and salience may better address disease-specific mechanisms contributing to disordered eating-and may also enhance adherence and motivation, and thereby improve outcomes.

The authors report no conflicts of interest concerning the subject matter of this article. Are extremes of consumption in eating disorders related to an altered balance between reward and inhibition? Front Behav Neurosci.

Altered insula response to sweet taste processing after recovery from anorexia and bulimia nervosa. Am J Psychiatry. Altered striatal response to reward in bulimia nervosa after recovery. Int J Eat Disord. Altered reward processing in women recovered from anorexia nervosa. Hunger does not motivate reward in women remitted from anorexia nervosa. Biol Psychiatry. An fMRI study of self-regulatory control and conflict resolution in adolescents with bulimia nervosa.

Aberrant brain activation during a response inhibition task in adolescent eating disorder subtypes. Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat Rev Neurosci. Does a shared neurobiology for foods and drugs of abuse contribute to extremes of food ingestion in anorexia. Fluoxetine in the treatment of bulimia nervosa: a multicenter, placebo-controlled, double-blind trial.

Arch Gen Psychiatry. Efficacy and safety of lisdexamfetamine for treatment of adults with moderate to severe binge-eating disorder: a randomized clinical trial. JAMA Psychiatry. World J Biol Psychiatry.

New insights into symptoms and neurocircuit function of anorexia nervosa

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New insights into neural pathways that play a role in anorexia nervosa, bulimia nervosa, and binge eating disorder. Eating disorder behaviors can range from dangerous caloric restriction to eating that feels out of control-often combined with unhealthy weight control behaviors, such as self-induced vomiting or laxative abuse. Anorexia nervosa, bulimia nervosa, and binge eating disorder are the most prevalent eating disorders. Criteria for bulimia nervosa include recurrent binge eating eating a large amount of food in a discrete period of time accompanied by a sense of loss of control and actions meant to counteract weight gain eg, self-induced vomiting , as well as overvaluation of body weight or shape. Binge eating disorder involves recurrent binge eating without inappropriate compensatory behavior. Individuals with eating disorders frequently report extreme body dissatisfaction, anhedonia, anxiety, and difficulty tolerating negative emotions, although these are not required for diagnosis.


New insights into symptoms and neurocircuit function of anorexia nervosa. Nat Rev Neurosci September ; Nature Reviews.


New Insights in Anorexia Nervosa

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COMMENT 3

  • Anorexia nervosa AN is classically defined as a condition in which an abnormally low body weight is associated with an intense fear of gaining weight and distorted cognitions regarding weight, shape, and drive for thinness. Emelina P. - 17.05.2021 at 19:58
  • Anorexia nervosa AN is classically defined as a condition in which an abnormally low body weight is associated with an intense fear of gaining weight and distorted cognitions regarding weight, shape, and drive for thinness. Patty B. - 19.05.2021 at 09:31
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